The Ups and Downs of Non-Insulin Therapies: The Agony of Choice

  • Roger Chen St Vincent’s Hospital, Sydney Conjoint Associate Professor, University of New South Wales Clinical Associate Professor, University of Sydney Visiting Scientist, Garvan Institute of Medical Research, New South Wales, Australia
  • Ashish Munsif Endocrinology Registrar, Nepean Hospital, Sydney, New South Wales, Australia
DOI: https://doi.org/10.7175/cmi.v13i1.1426

References

Davies MJ, D’Alessio DA, Fradkin J, et al. Management of hyperglycaemia in type 2 diabetes, 2018. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetologia 2018; 61: 2461-98; https://doi.org/10.1007/s00125-018-4729-5

Zinman B, Wanner C, Lachin JM, et al.; EMPA-REG OUTCOME Investigators. Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes. N Engl J Med 2015; 373: 2117-28; https://doi.org/10.1056/NEJMoa1504720

Neal B, Perkovic V, Matthews DR. Canagliflozin and Cardiovascular and Renal Events in Type 2 Diabetes. N Engl J Med 2017; 377: 644-57; https://doi.org/10.1056/NEJMc1712572

Wiviott SD, Raz I, Bonaca MP, et al.; DECLARE–TIMI 58 Investigators. Dapagliflozin and Cardiovascular Outcomes in Type 2 Diabetes. N Engl J Med 2019; 380: 347-57; https://doi.org/10.1056/NEJMoa1812389

Hamblin PS, Wong R, Ekinci EI, et al. SGLT2 Inhibitors Increase the Risk of Diabetic Ketoacidosis Developing in the Community and During Hospital Admission. J Clin Endocrinol Metab 2019 Mar 5. pii: jc.2019-00139; https://doi.org/10.1210/jc.2019-00139

Wu JH, Foote C, Blomster J, et al. Effects of sodium-glucose cotransporter-2 inhibitors on cardiovascular events, death, and major safety outcomes in adults with type 2 diabetes: a systematic review and meta-analysis. Lancet Diabetes Endocrinol 2016; 4: 411-9; https://doi.org/10.1016/S2213-8587(16)00052-8

Jardine MJ, Mahaffey KW, Neal B, et al.; CREDENCE study investigators. The Canagliflozin and Renal Endpoints in Diabetes with Established Nephropathy Clinical Evaluation (CREDENCE) Study Rationale, Design, and Baseline Characteristics. Am J Nephrol 2017; 46: 462-72; https://doi.org/10.1159/000484633

Scirica BM, Bhatt DL, Braunwald E, et al.; SAVOR-TIMI 53 Steering Committee and Investigators. Saxagliptin and cardiovascular outcomes in patients with type 2 diabetes mellitus. N Engl J Med 2013; 369: 1317-26; https://doi.org/10.1056/NEJMoa1307684

Marso SP, Daniels GH, Brown-Frandsen K, et al.; LEADER Steering Committee; LEADER Trial Investigators. Liraglutide and Cardiovascular Outcomes in Type 2 Diabetes. N Engl J Med 2016; 375: 311-22; https://doi.org/10.1056/NEJMoa1603827

Marso SP, Bain SC, Consoli A, et al.; SUSTAIN-6 Investigators. Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes. N Engl J Med 2016; 375: 1834-44; https://doi.org/10.1056/NEJMoa1607141

Pfeffer MA, Claggett B, Diaz R, et al.; ELIXA Investigators. Lixisenatide in Patients with Type 2 Diabetes and Acute Coronary Syndrome. N Engl J Med 2015; 373: 2247-57; https://doi.org/10.1056/NEJMoa1509225

Holman RR, Bethel MA, Mentz RJ, et al.; EXSCEL Study Group. Effects of Once-Weekly Exenatide on Cardiovascular Outcomes in Type 2 Diabetes. N Engl J Med 2017; 377: 1228-39; https://doi.org/10.1056/NEJMoa1612917

Dormandy JA, Charbonnel B, Eckland DJ, et al.; PROactive Investigators. Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive Study (PROspective pioglitAzone Clinical Trial In macroVascular Events): a randomised controlled trial. Lancet 2005; 366: 1279-89; https://doi.org/10.1016/S0140-6736(05)67528-9

Graham DJ, Ouellet-Hellstrom R, MaCurdy TE, et al. Risk of acute myocardial infarction, stroke, heart failure, and death in elderly Medicare patients treated with rosiglitazone or pioglitazone. JAMA 2010; 304: 411-8; https://doi.org/10.1001/jama.2010.920

Abdul-Ghani MA, Puckett C, Triplitt C, et al. Initial combination therapy with metformin, pioglitazone and exenatide is more effective than sequential add-on therapy in subjects with new-onset diabetes. Results from the Efficacy and Durability of Initial Combination Therapy for Type 2 Diabetes (EDICT): a randomized trial. Diabetes Obes Metab 2015; 17: 268-75; https://doi.org/10.1111/dom.12417

Published
2019-04-03
Issue
Vol 13 No 1 (2019)
Section
Editorial

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